Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca-ATPase (SERCA) in a mouse model of Sandhoff disease, and prevention by treatment with N-butyldeoxynojirimycin
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Inhibition of calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin.
Gangliosides are found at high levels in neuronal tissues where they play a variety of important functions. In the gangliosidoses, gangliosides accumulate because of defective activity of the lysosomal proteins responsible for their degradation, usually resulting in a rapidly progressive neurodegenerative disease. However, the molecular mechanism(s) leading from ganglioside accumulation to neur...
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BACKGROUND Hypercholesterolemia (HC) impairs acetylcholine-induced relaxation but has little effect on that caused by the NO donor sodium nitroprusside (SNP), suggesting that acetylcholine releases less NO from the endothelium in HC. The relaxation to authentic NO gas, however, is also impaired in HC aortic smooth muscle, indicating an abnormal smooth muscle response. NO relaxes arteries by bot...
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Pancreatic -cells maintain glucose homeostasis by their regulated Ca -dependent secretion of insulin. Several cellular mechanisms control intracellular Ca levels, but their relative significance in mouse -cells is not fully known. We used photometry to measure the dynamics of cytosolic Ca ([Ca ]i) clearance after brief, depolarization-induced Ca entry. Treatment with thapsigargin or cyclopiazon...
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We have previously characterized an insulin receptor substrate 1 (IRS-1)-overexpressing beta-cell line. These beta-cells demonstrated elevated fractional insulin secretion and elevated cytosolic Ca(2+) levels compared with wild-type and vector controls. This effect of IRS-1 may be mediated via an interaction with the sarco-endoplasmic reticulum calcium ATPase (SERCA). Here we demonstrate that I...
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